Building and analysing an integrative model of HIV-1 RNA alternative splicing

Authors:
A. Bockmayr;A. Courtois;D. Eveillard;M. Vezain
Affiliations:
LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy), Vandœuvre-lès-Nancy, France;LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy), Vandœuvre-lès-Nancy, France;LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy), Vandœuvre-lès-Nancy, France;LORIA, UMR 7503 (CNRS, INRIA, Universités de Nancy), Vandœuvre-lès-Nancy, France
Venue:
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
Year:
2004

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Abstract

We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.