Evaluating theories of immunological memory using large-scale simulations

Authors:
M. J. Robbins;S. M. Garrett
Affiliations:
Computational Biology Group, Dept. Computer Science, University of Wales, UK;Computational Biology Group, Dept. Computer Science, University of Wales, UK
Venue:
ICARIS'05 Proceedings of the 4th international conference on Artificial Immune Systems
Year:
2005

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Abstract

Immunological simulations offer the possibility of performing high-throughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this paper, we first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. We conclude that the theory appears valid, but that there are a common set of reasons why simulations are a useful support tool, not conclusive in themselves.