Mathematical Analysis of HIV-1 Dynamics in Vivo
SIAM Review
Dynamics of complex systems
Artificial Immune Systems: A New Computational Intelligence Paradigm
Artificial Immune Systems: A New Computational Intelligence Paradigm
breve: a 3D environment for the simulation of decentralized systems and artificial life
ICAL 2003 Proceedings of the eighth international conference on Artificial life
Granularity and the validation of agent-based models
Proceedings of the 2008 Spring simulation multiconference
A Hybrid Agent-Based Model of Chemotaxis
ICCS '07 Proceedings of the 7th international conference on Computational Science, Part I: ICCS 2007
The swarming body: simulating the decentralized defenses of immunity
ICARIS'06 Proceedings of the 5th international conference on Artificial Immune Systems
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Considerable research effort has provided mathematical and computational models of the human immune response under viral infection. However, the quality of simulated results are highly dependent on the choice of modeling strategy. We examine two modeling approaches of HIV pathogenesis: Mathematical and Multi-Agent (or MA) Models. The latter has relatively wider Model Scope due to the agent-rule specification method. Mathematical Models employ Parameter and Population/Subpopulation Level entity granularities with equation-based interaction, while MA Models specify entities at Individual Level, implemented with agents to describe interactions via IF-THEN rules. Compared to the former, MA Models naturally handles entity heterogeneity and spatial non-uniformity, and suffers less from the issue of directly designed dynamics. Both approaches are however, not directly accessible to immunologists due to the need for programming knowledge; hence, closer collaboration between computer scientists and immunologists is necessary.