Real time decision support system for diagnosis of rare cancers, trained in parallel, on a graphics processing unit

Authors:
Konstantinos Sidiropoulos;Dimitrios Glotsos;Spiros Kostopoulos;Panagiota Ravazoula;Ioannis Kalatzis;Dionisis Cavouras;John Stonham
Affiliations:
School of Engineering and Design, Brunel University West London, Uxbridge, Middlesex, UB8 3PH, UK;Department of Medical Instruments Technology, Technological Educational Institute of Athens, Ag. Spyridonos, Egaleo, Athens, 12210, Greece;Department of Medical Instruments Technology, Technological Educational Institute of Athens, Ag. Spyridonos, Egaleo, Athens, 12210, Greece;Department of Pathology, University Hospital of Patras, Rio, Patras 265 00, Greece;Department of Medical Instruments Technology, Technological Educational Institute of Athens, Ag. Spyridonos, Egaleo, Athens, 12210, Greece;Department of Medical Instruments Technology, Technological Educational Institute of Athens, Ag. Spyridonos, Egaleo, Athens, 12210, Greece;School of Engineering and Design, Brunel University West London, Uxbridge, Middlesex, UB8 3PH, UK
Venue:
Computers in Biology and Medicine
Year:
2012

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Abstract

In the present study a new strategy is introduced for designing and developing of an efficient dynamic Decision Support System (DSS) for supporting rare cancers decision making. The proposed DSS operates on a Graphics Processing Unit (GPU) and it is capable of adjusting its design in real time based on user-defined clinical questions in contrast to standard CPU implementations that are limited by processing and memory constrains. The core of the proposed DSS was a Probabilistic Neural Network classifier and was evaluated on 140 rare brain cancer cases, regarding its ability to predict tumors' malignancy, using a panel of 20 morphological and textural features Generalization was estimated using an external 10-fold cross-validation. The proposed GPU-based DSS achieved significantly higher training speed, outperforming the CPU-based system by a factor that ranged from 267 to 288 times. System design was optimized using a combination of 4 textural and morphological features with 78.6% overall accuracy, whereas system generalization was 73.8%+/-3.2%. By exploiting the inherently parallel architecture of a consumer level GPU, the proposed approach enables real time, optimal design of a DSS for any user-defined clinical question for improving diagnostic assessments, prognostic relevance and concordance rates for rare cancers in clinical practice.