From syntax to semantics in systems biology towards automated reasoning tools

  • Authors:
  • François Fages

  • Affiliations:
  • Projet Contraintes, INRIA Rocquencourt, Le Chesnay, France

  • Venue:
  • Transactions on Computational Systems Biology IV
  • Year:
  • 2006

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Abstract

Mathematical biology has for a long time investigated the dynamics of biomolecular systems by developing numerical models involving (highly non-linear) differential equations and using tools such as Bifurcation Theory for estimating parameters [1]. Mathematical biology provides a firm ground for the numerical analysis of biological systems. However, state-of-the-art quantitative models can hardly be re-used and composed with other models in a systematic fashion, and are limited to a few tenths of variables [2].