Niching methods for genetic algorithms
Niching methods for genetic algorithms
Estimation of Distribution Algorithms: A New Tool for Evolutionary Computation
Estimation of Distribution Algorithms: A New Tool for Evolutionary Computation
A complete and effective move set for simplified protein folding
RECOMB '03 Proceedings of the seventh annual international conference on Research in computational molecular biology
Crossover, Macromutationand, and Population-Based Search
Proceedings of the 6th International Conference on Genetic Algorithms
An analysis of the behavior of a class of genetic adaptive systems.
An analysis of the behavior of a class of genetic adaptive systems.
Novel Memetic Algorithm for Protein Structure Prediction
AI '09 Proceedings of the 22nd Australasian Joint Conference on Advances in Artificial Intelligence
On Lattice Protein Structure Prediction Revisited
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
An Immune Algorithm for Protein Structure Prediction on Lattice Models
IEEE Transactions on Evolutionary Computation
Protein Folding in Simplified Models With Estimation of Distribution Algorithms
IEEE Transactions on Evolutionary Computation
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Most population based evolutionary algorithms (EAs) have struggled to accurately predict structure for long protein sequences. This is because conventional operators, i.e., crossover and mutation, cannot satisfy constraints (e.g., connected chain and self-avoiding-walk) of the complex combinatorial multi-modal problem, protein structure prediction (PSP). In this paper, we present novel crossover and mutation operators based on conflict resolution for handling long protein sequences in PSP using lattice models. To our knowledge, this is a pioneering work to address the PSP limitations for long sequences. Experiments carried out with long PDB sequences show the effectiveness of the proposed method.