Information Sciences—Informatics and Computer Science: An International Journal
MICCAI '98 Proceedings of the First International Conference on Medical Image Computing and Computer-Assisted Intervention
A hierarchical genetic algorithm for segmentation of multi-spectral human-brain MRI
Expert Systems with Applications: An International Journal
Cluster analysis of genome-wide expression data for feature extraction
Expert Systems with Applications: An International Journal
Mining whole-sample mass spectrometry proteomics data for biomarkers - An overview
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Pattern Recognition Letters
18F-FDG PET imaging analysis for computer aided Alzheimer's diagnosis
Information Sciences: an International Journal
WBCD breast cancer database classification applying artificial metaplasticity neural network
Expert Systems with Applications: An International Journal
HAIS'10 Proceedings of the 5th international conference on Hybrid Artificial Intelligence Systems - Volume Part I
On the empirical mode decomposition applied to the analysis of brain SPECT images
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Deformation based feature selection for Computer Aided Diagnosis of Alzheimer's Disease
Expert Systems with Applications: An International Journal
Expert Systems with Applications: An International Journal
Functional activity maps based on significance measures and Independent Component Analysis
Computer Methods and Programs in Biomedicine
Computer-aided diagnosis system: A Bayesian hybrid classification method
Computer Methods and Programs in Biomedicine
Hi-index | 12.06 |
An accurate and early diagnosis of the Alzheimer's Disease (AD) is of fundamental importance for the development of effective treatments to palliate the effects of the disease. Computer Aided Diagnosis (CAD) allows physicians to detect early stages of the disease, and functional brain images have been proved to be very useful in this task. This paper presents a new CAD system that consists of three stages: voxel selection, feature extraction and classification. Voxels are selected in terms of their significance, by using Mann-Whitney-Wilcoxon U-Test. Then, Factor Analysis is proposed to carry out the feature reduction step, by extracting common factors and factor loadings from the selected voxels. Finally, a Linear Support Vector Machine (SVM) classifier is trained to perform clustering of the input images. Two different databases are considered for testing the proposed methods: the first one, consists of 96 Single Photon Emission Computed Tomography (SPECT) images from the ''Virgen de las Nieves'' Hospital in Granada, Spain, and a 196 Positron Emission Tomography (PET) database from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The proposed method achieves accuracy results of up to 93.7% and 92.9% for SPECT and PET images respectively, and reports benefits over recently reported methods.