Automated approaches for analysis of multimodal MRI acquisitions in a study of cognitive aging

Authors:
Erlend Hodneland;Martin Ystad;Judit Haasz;Antonella Munthe-Kaas;Arvid Lundervold
Affiliations:
Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway and Department of Mathematics, University of Bergen, N-5020 Bergen, Norway;Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway;Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway and Department of Mathematics, University of Bergen, N-5020 Bergen, Norway and Department of Radiology, Haukeland University ...;Department of Mathematics, University of Bergen, N-5020 Bergen, Norway;Department of Biomedicine, University of Bergen, N-5009 Bergen, Norway and Department of Radiology, Haukeland University Hospital, Bergen, Norway
Venue:
Computer Methods and Programs in Biomedicine
Year:
2012

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Abstract

In this work we describe an integrated and automated workflow for a comprehensive and robust analysis of multimodal MR images from a cohort of more than hundred subjects. Image examinations are done three years apart and consist of 3D high-resolution anatomical images, low resolution tensor-valued DTI recordings and 4D resting state fMRI time series. The integrated analysis of the data requires robust tools for segmentation, registration and fiber tracking, which we combine in an automated manner. Our automated workflow is strongly desired due to the large number of subjects. Especially, we introduce the use of histogram segmentation to processed fMRI data to obtain functionally important seed and target regions for fiber tracking between them. This enables analysis of individually important resting state networks. We also discuss various approaches for the assessment of white matter integrity parameters along tracts, and in particular we introduce the use of functional data analysis (FDA) for this task.