Microscopic image analysis for quantitative measurement and feature identification of normal and cancerous colonic mucosa

  • Authors:
  • A. Nasser Esgiar;R. N.G. Naguib;B. S. Sharif;M. K. Bennett;A. Murray

  • Affiliations:
  • Dept. of Electr. & Electron. Eng., Newcastle upon Tyne Univ., UK;-;-;-;-

  • Venue:
  • IEEE Transactions on Information Technology in Biomedicine
  • Year:
  • 1998

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Abstract

The development of an automated algorithm for the categorization of normal and cancerous colon mucosa is reported. Six features based on texture analysis were studied. They were derived using the co-occurrence matrix and were angular second moment, entropy, contrast, inverse difference moment, dissimilarity, and correlation. Optical density was also studied. Forty-four normal images and 58 cancerous images from sections of the colon were analyzed. These two groups were split equally into two subgroups: one set was used for supervised training and the other to test the classification algorithm. A stepwise selection procedure showed that correlation and entropy were the features that discriminated most strongly between normal and cancerous tissue (P