Visualization and comparison of DNA sequences by use of three-dimensional trajectories
APBC '03 Proceedings of the First Asia-Pacific bioinformatics conference on Bioinformatics 2003 - Volume 19
PRIB'06 Proceedings of the 2006 international conference on Pattern Recognition in Bioinformatics
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Jeffrey proposed (1990) a graphic representation of DNA sequences using Barnsley's iterative function systems. In spite of further developments in this direction, the proposed graphic representation of DNA sequences has been lacking a rigorous connection between its spatial scaling characteristics and the statistical characteristics of the DNA sequences themselves. We 1) generalize Jeffrey's graphic representation to accommodate (possibly infinite) sequences over an arbitrary finite number of symbols; 2) establish a direct correspondence between the statistical characterization of symbolic sequences via Renyi entropy spectra (1959) and the multifractal characteristics (Renyi generalized dimensions) of the sequences' spatial representations; 3) show that for general symbolic dynamical systems, the multifractal fH-spectra in the sequence space coincide with the fH -spectra on spatial sequence representations