Brief Communication: Detection of potential positive regulatory motifs of transcription in yeast introns by comparative analysis of oligonucleotide frequencies

Authors:
Jing Zhang;Jun Hu;Xiu-Fan Shi;Huai Cao;Wei-Bo Liu
Affiliations:
The Center of Applied Statistics, Yunnan University, Kunming 650091, China and Department of Computer Science, Yunnan University of Finance and Economics, Kunming 650221, China;The Center of Applied Statistics, Yunnan University, Kunming 650091, China;Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, China;The Center of Modern Biology, Yunnan University, Kunming 650091, China;The Center of Modern Biology, Yunnan University, Kunming 650091, China
Venue:
Computational Biology and Chemistry
Year:
2003

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Abstract

We conducted a comparative statistical analysis of tetra- through hexanucleotide frequencies in two sets of introns of yeast genes. The first set consisted of introns of genes that have transcription rates higher than 30 mRNAs/h while the second set contained introns of genes whose transcription rates were lower than or equal to 10 mRNAs/h. Some oligonucleotides whose occurrence frequencies in the first set of introns are significantly higher than those in the second set of introns were detected. The frequencies of occurrence of most of these detected oligonucleotides are also significantly higher than those in the exons flanking the introns of the first set. Interestingly some of these detected oligonucleotides are the same as well known ''signature'' sequences of transcriptional regulatory elements. This could imply the existence of potential positive regulatory motifs of transcription in yeast introns.