Intelligence through simulated evolution: forty years of evolutionary programming
Intelligence through simulated evolution: forty years of evolutionary programming
Multi-Objective Optimization Using Evolutionary Algorithms
Multi-Objective Optimization Using Evolutionary Algorithms
Genetic Algorithms for Multiobjective Optimization: FormulationDiscussion and Generalization
Proceedings of the 5th International Conference on Genetic Algorithms
FMGA: Finding Motifs by Genetic Algorithm
BIBE '04 Proceedings of the 4th IEEE Symposium on Bioinformatics and Bioengineering
MDGA: motif discovery using a genetic algorithm
GECCO '05 Proceedings of the 7th annual conference on Genetic and evolutionary computation
Comparison of Multiobjective Evolutionary Algorithms: Empirical Results
Evolutionary Computation
MOGAMOD: Multi-objective genetic algorithm for motif discovery
Expert Systems with Applications: An International Journal
Handbook of Parametric and Nonparametric Statistical Procedures
Handbook of Parametric and Nonparametric Statistical Procedures
Bacterial Foraging Optimization Algorithm Integrating Tabu Search for Motif Discovery
BIBM '09 Proceedings of the 2009 IEEE International Conference on Bioinformatics and Biomedicine
Motif Discovery Using Evolutionary Algorithms
SOCPAR '09 Proceedings of the 2009 International Conference of Soft Computing and Pattern Recognition
Finding motifs in DNA sequences applying a multiobjective artificial bee colony (MOABC) algorithm
EvoBIO'11 Proceedings of the 9th European conference on Evolutionary computation, machine learning and data mining in bioinformatics
A fast and elitist multiobjective genetic algorithm: NSGA-II
IEEE Transactions on Evolutionary Computation
A faster algorithm for calculating hypervolume
IEEE Transactions on Evolutionary Computation
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Multiobjective optimization is successfully applied in many biological problems. Currently, most biological problems require to optimize more than one single objective at the same time, resulting in Multiobjective Optimization Problems (MOP). In the last years, multiple metaheuristics have been successfully used to solve optimization problems. However, many of them are designed to solve problems with only one objective function. In this work, we study several multiobjective adaptations to solve one of the most important biological problems, the Motif Discovery Problem (MDP). MDP aims to discover novel Transcription Factor Binding Sites (TFBS) in DNA sequences, maximizing three conflicting objectives: motif length, support, and similarity. For this purpose, we have used the Artificial Bee Colony algorithm, a novel Swarm Intelligence algorithm based on the intelligent behavior of honey bees. As we will see, the use of one or another multiobjective adaptation causes significant differences in the results.