Ab initio reconstruction and experimental design for cryo electron microscopy

Authors:
P. C. Doerschuk;J. E. Johnson
Affiliations:
Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN;-
Venue:
IEEE Transactions on Information Theory
Year:
2006

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Abstract

A statistical model for the object and the complete image formation process in the cryo electron microscopy of viruses is presented. Using this model, maximum-likelihood reconstructions of the three-dimensional (3-D) structure of viruses are computed using the expectation maximization algorithm, and alternative experimental designs are evaluated based on Cramer-Rao bounds. Numerical examples of the reconstructions and experimental design evaluations are provided based on Cowpea mosaic virus