Visualization Research Challenges: A Report Summary
Computing in Science and Engineering
Computational Approaches for Automatic Structural Analysis of Large Biomolecular Complexes
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Flexibility description of the MET protein stalk based on the use of non-uniform B-splines
CAIP'07 Proceedings of the 12th international conference on Computer analysis of images and patterns
A multiscale model for virus capsid dynamics
Journal of Biomedical Imaging - Special issue on mathematical methods for images and surfaces
Image processing system for localising macromolecules in cryo-electron tomography
Machine Graphics & Vision International Journal
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Secondary and tertiary structural fold elucidation from 3d EM maps of macromolecules
ICVGIP'06 Proceedings of the 5th Indian conference on Computer Vision, Graphics and Image Processing
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We present an automatic algorithm to segment all the local and global asymmetric units of a three-dimensional density map of icosahedral viruses. This approach is readily applicable to the structural analysis of a broad range of virus structures that are reconstructed using cryo-electron microscopy (cryo-EM) technique. Our algorithm includes three major steps operating on the three dimensional density map: the detection of critical points of the volumetric density function, the detection of global and local symmetry axes, and, finally, the boundary segmentation of all the asymmetric units. We demonstrate the efficacy of our algorithm and report our results on several experimental volumetric datasets, consisting of both reconstructed cryo-EM molecular density maps taken from the European Bioinformatics Institute archive, as well our own synthetically generated (blurred) maps calculated from X-ray resolution molecular structural data taken from the Protein Data Bank.