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This paper presents the design and implementation of a new High-Performance Computing (HPC) course. This course amalgamates the emerging trend of data-intensive cloud computing with the dominant innovation of multicore computing and the important legacy of cluster computing. While others have reported the development of novel HPC courses, we are the first, to our knowledge, to report an upper-level HPC course that introduces the increasingly popular data-intensive cloud computing paradigm - integrally with the better-established shared memory and message-passing models. This course is entirely based on free digital reading resources and open source software. The course's design rationale and implementation - including the use of open source software tools and reading resources - may be beneficial for educators who need to design HPC courses or modules, and especially for those who wish to cover data-intensive cloud computing.