IVUS-histology image registration

  • Authors:
  • Amin Katouzian;Athanasios Karamalis;Jennifer Lisauskas;Abouzar Eslami;Nassir Navab

  • Affiliations:
  • Computer Aided Medical Procedures (CAMP), Technical University of Munich, Germany, Biomedical Engineering Department, Columbia University, New York;Computer Aided Medical Procedures (CAMP), Technical University of Munich, Germany;Infraredx® Inc, Burlington, MA;Computer Aided Medical Procedures (CAMP), Technical University of Munich, Germany, Institut für Biomathematik und Biometrie, Helmholtz Zentrum München, Germany;Computer Aided Medical Procedures (CAMP), Technical University of Munich, Germany

  • Venue:
  • WBIR'12 Proceedings of the 5th international conference on Biomedical Image Registration
  • Year:
  • 2012

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Abstract

In this paper, for the first time, we present a systematic framework to register intravascular ultrasound (IVUS) images with histology correspondences. We deployed intermediate representations of images, generating segmentation masks corresponding to lumen and media-adventitia borders for both histology and IVUS images, incorporated into a non-rigid registration framework using discrete multi-labeling and approximate curvature penalty for smoothness regularization. The resulting deformation field was then applied to the original histology image to transfer it to IVUS coordinate system. Finally, the results were quantified on 14 cross sections of interest. The main contribution of this work is that the registered results could be used for systematic labeling of tissues, which ultimately will lead to reliable construction of training dataset for feature extraction and supervised classification of atherosclerotic tissues.