A compositional approach to performance modelling
A compositional approach to performance modelling
Brownian simulation of many-particle binding to a reversible receptor array
Journal of Computational Physics
A Calculus of Communicating Systems
A Calculus of Communicating Systems
BioAmbients: an abstraction for biological compartments
Theoretical Computer Science - Special issue: Computational systems biology
Modelling Biological Compartments in Bio-PEPA
Electronic Notes in Theoretical Computer Science (ENTCS)
CiE'10 Proceedings of the Programs, proofs, process and 6th international conference on Computability in Europe
Osteoporosis: a multiscale modeling viewpoint
Proceedings of the 9th International Conference on Computational Methods in Systems Biology
A Combined Process Algebraic and Stochastic Approach to Bone Remodeling
Electronic Notes in Theoretical Computer Science (ENTCS)
Beta binders for biological interactions
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
The attributed pi-calculus with priorities
Transactions on Computational Systems Biology XII
Spatial modeling in cell biology at multiple levels
Proceedings of the Winter Simulation Conference
Multiple verification in complex biological systems: the bone remodelling case study
Transactions on Computational Systems Biology XIV
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Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and intercellular RANK/RANKL signaling to tissue dynamics, by developing a multilevel modeling framework. Several important findings provide clear evidences of the multiscale properties of bone formation and of the links between RANK/RANKL and bone density in healthy and disease conditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone turnover and Bone Mineral Density (BMD) and contribute to the development of osteoporosis in postmenopausal women, and thalassemic patients. We make use of a spatial process algebra, the Shape Calculus, to control stochastic cell agents that are continuously remodeling the bone. We found that our description is effective for such a multiscale, multilevel process and that RANKL signaling small dynamic concentration defects are greatly amplified by the continuous alternation of absorption and formation resulting in large structural bone defects. This work contributes to the computational modeling of complex systems with a multilevel approach connecting formal languages and agent-based simulation tools.