Incremental Development of a Distributed Real-Time Model of a Cardiac Pacing System Using VDM
FM '08 Proceedings of the 15th international symposium on Formal Methods
Formal Specification of a Cardiac Pacing System
FM '09 Proceedings of the 2nd World Congress on Formal Methods
Real-Time Heart Model for Implantable Cardiac Device Validation and Verification
ECRTS '10 Proceedings of the 2010 22nd Euromicro Conference on Real-Time Systems
Modeling and Verification of Safety Critical Systems: A Case Study on Pacemaker
SSIRI '10 Proceedings of the 2010 Fourth International Conference on Secure Software Integration and Reliability Improvement
Statistical model checking: an overview
RV'10 Proceedings of the First international conference on Runtime verification
PRISM 4.0: verification of probabilistic real-time systems
CAV'11 Proceedings of the 23rd international conference on Computer aided verification
Safety-assured development of the GPCA infusion pump software
EMSOFT '11 Proceedings of the ninth ACM international conference on Embedded software
Modeling and verification of a dual chamber implantable pacemaker
TACAS'12 Proceedings of the 18th international conference on Tools and Algorithms for the Construction and Analysis of Systems
CMSB'12 Proceedings of the 10th international conference on Computational Methods in Systems Biology
Quantitative Verification of Implantable Cardiac Pacemakers
RTSS '12 Proceedings of the 2012 IEEE 33rd Real-Time Systems Symposium
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We develop a novel hybrid heart model in Simulink that is suitable for quantitative verification of implantable cardiac pacemakers. The heart model is formulated at the level of cardiac cells, can be adapted to patient data, and incorporates stochasticity. It is inspired by the timed and hybrid automata network models of Jiang et al and Ye et al, where probabilistic behaviour is not considered. In contrast to our earlier work, we work directly with action potential signals that the pacemaker sensor inputs from a specific cell, rather than ECG signals. We validate the model by demonstrating that its composition with a pacemaker model can be used to check safety properties by means of approximate probabilistic verification.