A clustering algorithm based on graph connectivity
Information Processing Letters
Genetic Algorithms in Search, Optimization and Machine Learning
Genetic Algorithms in Search, Optimization and Machine Learning
Applying Two-Level Simulated Annealing on Bayesian Structure Learning to Infer Genetic Networks
CSB '04 Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference
Optimizing time series discretization for knowledge discovery
Proceedings of the eleventh ACM SIGKDD international conference on Knowledge discovery in data mining
The Journal of Machine Learning Research
Inferring Gene Regulatory Networks using Differential Evolution with Local Search Heuristics
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Bioinformatics
A Markov-Blanket-Based Model for Gene Regulatory Network Inference
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Bioinformatics
Finding optimal bayesian networks
UAI'02 Proceedings of the Eighteenth conference on Uncertainty in artificial intelligence
AI'11 Proceedings of the 24th international conference on Advances in Artificial Intelligence
Hybridization of evolutionary algorithms and local search by means of a clustering method
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics
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Solutions for deriving the most consistent Bayesian gene regulatory network model from given data sets using evolutionary algorithms typically only result in locally optimal solutions. Further, due to genetic drift, merely increasing the size of the population does not overcome this limitation. In this paper, we propose a two-stage genetic algorithm that systematically searches the whole search space using frequent subgraph mining techniques. The approach finds representative patterns present in different local optimal solutions in the first stage and then combines these frequent subgraphs (motifs) in the second stage to converge to the global optima. We apply the algorithm to both synthetic and real life networks of yeast and E.coli and show the effectiveness of our approach.