Decision support system for Warfarin therapy management using Bayesian networks

Authors:
Barbaros Yet;Kaveh Bastani;Hendry Raharjo;Svante Lifvergren;William Marsh;Bo Bergman
Affiliations:
Department of Technology Management and Economics, Division of Quality Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden;Department of Technology Management and Economics, Division of Quality Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden;Department of Technology Management and Economics, Division of Quality Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden;The Skaraborg Hospital Group, 541 85, Skövde, Sweden;School of Electronic Engineering and Computer Science, Queen Mary, University of London, London E1 4NS, UK;Department of Technology Management and Economics, Division of Quality Sciences, Chalmers University of Technology, 412 96 Gothenburg, Sweden
Venue:
Decision Support Systems
Year:
2013

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Abstract

Warfarin therapy is known as a complex process because of the variation in the patients' response. Failure to deal with such variation may lead to death as a result of thrombosis or bleeding. The possible sources of variation such as concomitant illnesses and drug interactions have to be investigated by the clinician in order to deal with the variation. This paper describes a decision support system (DSS) using Bayesian networks for assisting clinicians to make better decisions in Warfarin therapy management. The DSS is developed in collaboration with a Swedish hospital group that manages Warfarin therapy for more than 3000 patients. The proposed model can assist the clinician in making dose-adjustment and follow-up interval decisions, investigating variation causes, and evaluating bleeding and thrombosis risks related to therapy. The model is built upon previous findings from medical literature, the knowledge of domain experts, and large dataset of patients.