A Simple Fixed Parameter Tractable Algorithm for Computing the Hybridization Number of Two (Not Necessarily Binary) Trees

  • Authors:
  • Teresa Piovesan;Steven Kelk

  • Affiliations:
  • Maastricht University, Maastricht;Maastricht University, Maastricht

  • Venue:
  • IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
  • Year:
  • 2013

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Abstract

Here, we present a new fixed parameter tractable algorithm to compute the hybridization number $(r)$ of two rooted, not necessarily binary phylogenetic trees on taxon set $({{\cal X}})$ in time $((6^r r!) \cdot poly(n))$, where $(n=\vert {{\cal X}}\vert)$. The novelty of this approach is its use of terminals, which are maximal elements of a natural partial order on $({{\cal X}})$, and several insights from the softwired clusters literature. This yields a surprisingly simple and practical bounded-search algorithm and offers an alternative perspective on the underlying combinatorial structure of the hybridization number problem.