Biomarkers in Immunology: from Concepts to Applications

  • Authors:
  • Ping Zhang;Lou Chitkushev;Vladimir Brusic;Guang Lan Zhang

  • Affiliations:
  • CSIRO, Melbourne, Australia, +61-395-458-027;MET Health Informatics Lab, Boston University, Boston, MA, +1-617-353-6771;Boston University and Dana-Farber Cancer Institute, Boston, MA, +1-617-632-3824;Boston University and Dana-Farber Cancer Institute, Boston, MA, +1-617-358-5164

  • Venue:
  • Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics
  • Year:
  • 2013

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Abstract

In this paper, we summarized the challenges and promises of the study of immune biomarkers. We reviewed key concepts in biomarker discovery and discussed the framework for applying these concepts in the study of the immune system and its effects on the disease -- cancer, infection, allergy, immunodeficiencies, and autoimmunity. The immune system plays a special role in biomarker discovery since it interacts with all other systems in the human body and immune biomarkers are relevant for large number of diseases.