The nature of statistical learning theory
The nature of statistical learning theory
Wrappers for feature subset selection
Artificial Intelligence - Special issue on relevance
Automatic Quantification of MS Lesions in 3D MRI Brain Data Sets: Validation of INSECT
MICCAI '98 Proceedings of the First International Conference on Medical Image Computing and Computer-Assisted Intervention
Pattern Recognition and Machine Learning (Information Science and Statistics)
Pattern Recognition and Machine Learning (Information Science and Statistics)
Local-Learning-Based Feature Selection for High-Dimensional Data Analysis
IEEE Transactions on Pattern Analysis and Machine Intelligence
A Survey on Graphical Methods for Classification Predictive Performance Evaluation
IEEE Transactions on Knowledge and Data Engineering
Machine learning in medical imaging
Machine Vision and Applications
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It is widely believed that human brain is a complicated network and many neurological disorders such as Alzheimer's disease (AD) are related to abnormal changes of the brain network architecture. In this work, we present a kernel-based method to establish a network for each subject using mean cortical thickness, which we refer to hereafter as the individual's network. We construct individual networks for 83 subjects, including AD patients and normal controls (NC), which are taken from the Open Access Series of Imaging Studies database. The network edge features are used to make prediction of AD/NC through the sophisticated machine learning technology. As the number of edge features is much more than that of samples, feature selection is applied to avoid the adverse impact of high-dimensional data on the performance of classifier. We use a hybrid feature selection that combines filter and wrapper methods, and compare the performance of six different combinations of them. Finally, support vector machines are trained using the selected features. To obtain an unbiased evaluation of our method, we use a nested cross validation framework to choose the optimal hyper-parameters of classifier and evaluate the generalization of the method. We report the best accuracy of 90.4 % using the proposed method in the leave-one-out analysis, outperforming that using the raw cortical thickness data by more than 10 %.