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PDAs are no longer just cute little gizmos to keep track of appointments and to-do lists. As these small computers become more powerful with every generation, the possibly of their being really useful in a meaningful way is also increasing. The medical campus of Virginia Commonwealth University has had a keen interest in handheld technology for a number of years, and there have been numerous projects developed that involve PDAs. The number of commercial and shareware health related applications available for PDAs has skyrocketed, which has added to the already growing interest on the medical campus. This paper will describe some of the innovative health- related PDA projects under way at VCU which include a project involving medical students who were given PDAs loaded with various medical reference software to use in their work with patients, a Nurse Anesthesia project that uses video clips of procedures downloaded to PDAs for quick reference by students in the field and a creative use of PDAs and scanners to record attendance during grand rounds in the Department of Surgery. In addition, this paper will describe efforts to stimulate interest in PDA technology on the academic campus of VCU by developing channels on the AvantGo web site to communicate content to students and faculty via their PDAs and by developing a suite of classroom management applications for the Palm OS. VCU is also implementing infrared kiosks around campus so that mobile PDA users can easily HotSync to the network to use email and download web clipping content. Other projects are under discussion such as the possibility of hosting a higher education PDA conference at which presentations can be made and ideas shared.