Introduction to Reinforcement Learning
Introduction to Reinforcement Learning
Metalearning and neuromodulation
Neural Networks - Computational models of neuromodulation
Acetylcholine in cortical inference
Neural Networks - Computational models of neuromodulation
Neural Networks - 2003 Special issue: Advances in neural networks research IJCNN'03
Memory encoding by theta phase precession in the hippocampal network
Neural Computation
Cognitive Map Formation Through Sequence Encoding by Theta Phase Precession
Neural Computation
A Model of Prefrontal Cortical Mechanisms for Goal-directed Behavior
Journal of Cognitive Neuroscience
2005 Special issue: Functional role of entorhinal cortex in working memory processing
Neural Networks - Special issue: Computational theories of the functions of the hippocampus
2005 Special issue: Hippocampal mechanisms for the context-dependent retrieval of episodes
Neural Networks - Special issue: Computational theories of the functions of the hippocampus
Design Principles and Constraints Underlying the Construction of Brain-Based Devices
Neural Information Processing
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Cholinergic and GABAergic innervation of the hippocampus plays an important role in human memory function and rat spatial navigation. Drugs which block acetylcholine receptors or enhance GABA receptor activation cause striking impairments in the encoding of new information. Lesions of the cholinergic innervation of the hippocampus reduce the amplitude of hippocampal theta rhythm and cause impairments in spatial navigation tasks, including the Morris water maze, eight-arm radial maze, spatial reversal and delayed alternation. Here, we review previous work on the role of cholinergic modulation in memory function, and we present a new model of the hippocampus and entorhinal cortex describing the interaction of these regions for goal-directed spatial navigation in behavioral tasks. These mechanisms require separate functional phases for: (1) encoding of pathways without interference from retrieval, and (2) retrieval of pathways for guiding selection of the next movement. We present analysis exploring how phasic changes in physiological variables during hippocampal theta rhythm could provide these different phases and enhance spatial navigation function.