DNA sequence design using templates

  • Authors:
  • Masanori Arita;Satoshi Kobayashi

  • Affiliations:
  • PRESTO, JST and Computational Biology Research Center, AIST 2-41-6 Aomi, Koto-ku, Tokyo 135-0064 JAPAN;Department of Computer Science, University of Electro-Communications 1-5-1 Chofugaoka, Chofu-shi, Tokyo 182-8585 JAPAN

  • Venue:
  • New Generation Computing
  • Year:
  • 2002

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Abstract

Sequence design is a crucial problem in information-based biotechnology such as DNA-based computation. We introduce a simple strategy named template method that systematically generates a set of sequences of length l such that any of its member will have approximately l/3 mismatches with other sequences, their complements, and the overlaps of their concatenations.