An Ant Colony System for DNA sequence design based on thermodynamics

  • Authors:
  • Tri Basuki Kurniawan;Noor Khafifah Khalid;Zuwairie Ibrahim;Marzuki Khalid;Martin Middendorf

  • Affiliations:
  • Universiti Teknologi Malaysia, UTM Skudai, Johor Darul Takzim, Malaysia;Universiti Teknologi Malaysia, UTM Skudai, Johor Darul Takzim, Malaysia;Universiti Teknologi Malaysia, UTM Skudai, Johor Darul Takzim, Malaysia;Universiti Teknologi Malaysia, UTM Skudai, Johor Darul Takzim, Malaysia;University of Leipzig, Leipzig, Germany

  • Venue:
  • ACST '08 Proceedings of the Fourth IASTED International Conference on Advances in Computer Science and Technology
  • Year:
  • 2008

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Abstract

Hybridization between a DNA sequence and its base-pairing complement is crucial to retrieve the information stored in DNA sequences and operate a computation operation in DNA computing. Therefore, much works have focused on designing the DNA sequences to archive a reliable molecular computation and many algorithms have been proposed to obtain a set of good DNA sequences. In this paper, Ant Colony System (ACS) is proposed to solve the DNA sequence design problem. ACS as a derivate from Ant Colony Optimization (ACO) is an improvement from Ant System (AS) that used some agents to get their solutions based on the pheromone in their colony. A model is prepared which consists of four nodes representing four DNA bases using nearest-neighbor thermodynamic parameter's Watson-Crick base pair ΔG°37 as the distance between nodes. The results of the proposed approach are compared with the other methods such as genetic algorithm and evolutionary algorithm.