Genetic Optimization of the EPR Spectral Parameters: Algorithm Implementation and Preliminary Results

  • Authors:
  • Bogdan Filipic;Janez Strancar

  • Affiliations:
  • -;-

  • Venue:
  • PPSN VI Proceedings of the 6th International Conference on Parallel Problem Solving from Nature
  • Year:
  • 2000

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Abstract

Electron paramagnetic resonance (EPR) spectroscopy is a nondestructive technique suitable for inspection of biological systems. Characterization of such a system is much more reliable when relevant spectral characteristics are extracted from a biophysical model of the system. To tune the model parameters, stochastic optimization techniques are used more and more frequently. Since many single-point algorithms require time-consuming preparation of promising starting points to produce reasonable results, we have addressed the problem with population-based, evolutionary computation approach. We have applied a genetic algorithm to the EPR spectral parameter optimization and evaluated it on synthetic spectra. Preliminary numerical experiments show the new approach is beneficial in that it produces satisfactory results and reduces the time a spectroscopist spends for navigating the optimization process.