Co-registration of Histological, Optical and MR Data of the Human Brain

Authors:
Eric Bardinet;Sébastien Ourselin;D. Dormont;Grégoire Malandain;D. Tandé;K. Parain;Nicholas Ayache;J. Yelnik
Affiliations:
-;-;-;-;-;-;-;-
Venue:
MICCAI '02 Proceedings of the 5th International Conference on Medical Image Computing and Computer-Assisted Intervention-Part I
Year:
2002

Citing 2
Cited 4

Block Matching: A General Framework to Improve Robustness of Rigid Registration of Medical Images

MICCAI '00 Proceedings of the Third International Conference on Medical Image Computing and Computer-Assisted Intervention
Fusion of Histological Sections and MR Images: Towards the Construction of an Atlas of the Human Basal Ganglia

MICCAI '01 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention

Parallelized segmentation of a serially sectioned whole human brain

Image and Vision Computing
Smooth 3-D Reconstruction for 2-D Histological Images

IPMI '09 Proceedings of the 21st International Conference on Information Processing in Medical Imaging
Retrospective cross-evaluation of an histological and deformable 3D atlas of the basal ganglia on series of parkinsonian patients treated by deep brain stimulation

MICCAI'05 Proceedings of the 8th international conference on Medical image computing and computer-assisted intervention - Volume Part II
Reconstruction of 3-D histology images by simultaneous deformable registration

MICCAI'11 Proceedings of the 14th international conference on Medical image computing and computer-assisted intervention - Volume Part II

Quantified Score

Hi-index	0.00

Visualization

Abstract

In order to allow accurate pre-operative localisation of functional targets in functional neurosurgery, we aim at constructing a three dimensional registrable cartography of the basal ganglia, based on histology. For doing this, a post mortem MR study was conducted on a cadaver's head, and the brain was then extracted and processed for histology. The post mortem MR image will allow to report the cartography on the patient's anatomy, by its registration with the patient's MR image. In this paper, we focus on the problem of co-registering the histological and post mortem MR data of the same subject. First, realignment of the histological sections into a reliable three dimensional volume is performed. Then the reconstructed volume is registered with the post mortem MR image. To insure three dimensional integrity of the histological reconstructed volume, a reference volume is first constructed from photographs of the unstained surface of the frozen brain. This reference is then used as an intermediate volume for, on the one hand, independant alignment of each histological section with its corresponding optical section and on the other hand, three dimensional registration with the post mortem MR image.