Finding the needle in the haystack: algorithms for conformational optimization
Computers in Physics
Fast and numerically stable parametric alignment of biosequences
RECOMB '97 Proceedings of the first annual international conference on Computational molecular biology
A simple iterative approach to parameter optimization
RECOMB '00 Proceedings of the fourth annual international conference on Computational molecular biology
Using the Fisher Kernel Method to Detect Remote Protein Homologies
Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology
Genes, Themes, and Microarrays: Using Information Retrieval for Large-Scale Gene Analysis
Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology
Fast Protein Fold Recognition and Accurate Sequence-Structure Alignment
Selected papers from the German Conference on Bioinformatics
Analysis of Gene Expression Data with Pathway Scores
Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology
FROST: Revisited and Distributed
IPDPS '05 Proceedings of the 19th IEEE International Parallel and Distributed Processing Symposium (IPDPS'05) - Workshop 7 - Volume 08
Optimal protein threading by cost-splitting
WABI'05 Proceedings of the 5th International conference on Algorithms in Bioinformatics
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The year 2000 will be remembered in history as the year in which the human genome has been sequenced. This marks the end of the pre-genomic era which was characterized by strong world-wide efforts to sequence the human genome and, in fact, ended significantly ahead of schedule. Today, we are at the entry of the probably much longer post-genomic era, which is characterized by the grand quest of making sense of the genomic text. This goal can only be achieved by a concerted effort involving biological experiments and computer analyses. Conquering the computer part is the task of the scientific field of computational biology or bioinformatics. Here we will describe two facets of computational biology. One is that of a discipline shaped by several grand challenge basic research problems. The other is that of a field driven by a strong demand for immediate answers to pressing practical problems in biotechnology, notably in pharmaceutics and medicine.