Fair attribution of functional contribution in artificial and biological networks

  • Authors:
  • Alon Keinan;Ben Sandbank;Claus C. Hilgetag;Isaac Meilijson;Eytan Ruppin

  • Affiliations:
  • School of Computer Sciences, Tel-Aviv University, Tel-Aviv, Israel;School of Computer Sciences, Tel-Aviv University, Tel-Aviv, Israel;School of Engineering and Science, International University Bremen, Bremen, Germany;School of Mathematical Sciences, Tel-Aviv University, Tel-Aviv, Israel;School of Computer Sciences and School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

  • Venue:
  • Neural Computation
  • Year:
  • 2004

Quantified Score

Hi-index 0.00

Visualization

Abstract

This letter presents the multi-perturbation Shapley value analysis (MSA), an axiomatic, scalable, and rigorous method for deducing causal function localization from multiple perturbations data. The MSA, based on fundamental concepts from game theory, accurately quantifies the contributions of network elements and their interactions, overcoming several shortcomings of previous function localization approaches. Its successful operation is demonstrated in both the analysis of a neurophysiological model and of reversible deactivation data. The MSA has a wide range of potential applications, including the analysis of reversible deactivation experiments, neuronal laser ablations, and transcranial magnetic stimulation "virtual lesions," as well as in providing insight into the inner workings of computational models of neurophysiological systems.