Computational geometry: an introduction
Computational geometry: an introduction
An O(EV log V) algorithm for finding a maximal weighted matching in general graphs
SIAM Journal on Computing
Algorithms for clustering data
Algorithms for clustering data
The design and analysis of spatial data structures
The design and analysis of spatial data structures
Machine vision
Clustering gene expression patterns
RECOMB '99 Proceedings of the third annual international conference on Computational molecular biology
An algorithm for clustering cDNAs for gene expression analysis
RECOMB '99 Proceedings of the third annual international conference on Computational molecular biology
Using Bayesian networks to analyze expression data
RECOMB '00 Proceedings of the fourth annual international conference on Computational molecular biology
Analysis techniques for microarray time-series data
RECOMB '01 Proceedings of the fifth annual international conference on Computational biology
Identifying gene regulatory networks from experimental data
Parallel Computing - new trends in high performance computing
Computers and Intractability: A Guide to the Theory of NP-Completeness
Computers and Intractability: A Guide to the Theory of NP-Completeness
Robust Parametric and Semi-Parametric Spot Fitting for Spot Array Images
Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology
Computers and Electronics in Agriculture
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The design and implementation of a computer vision system called DNAScan for the automated analysis of DNA hybridization images is presented. The hybridization of a DNA clone with a radioactively tagged probe manifests itself as a spot on the hybridization membrane. The imaging of the hybridization membranes and the automated analysis of the resulting images are imperative for high-throughput genomics experiments. A recursive segmentation procedure is designed and implemented to extract spotlike features in the hybridization images in the presence of a highly inhomogeneous background. Positive hybridization signals (hits) are extracted from the spotlike features using grouping and decomposition algorithms based on computational geometry. A mathematical model for the positive hybridization patterns and a Bayesian pattern classifier based on shape-based moments are proposed and implemented to distinguish between the clone-probe hybridization signals. Experimental results on real hybridization membrane images are presented.