The inverse source problem based on the radiative transfer equation in optical molecular imaging

Authors:
Alexander D. Klose;Vasilis Ntziachristos;Andreas H. Hielscher
Affiliations:
Departments of Biomedical Engineering and Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, NY 10027, USA;Center for Molecular Imaging Research, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA;Departments of Biomedical Engineering and Radiology, Columbia University, ET351 Mudd Building, MC 8904, 500 West 120th Street, New York, NY 10027, USA
Venue:
Journal of Computational Physics
Year:
2005

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Abstract

We present the first tomographic reconstruction algorithm for optical molecular imaging that is based on the equation of radiative transfer. The reconstruction code recovers the spatial distribution of fluorescent sources in highly scattering biological tissue. An objective function, which describes the discrepancy of measured near-infrared light with predicted numerical data on the tissue surface, is iteratively minimized to find a solution of the inverse source problem. At each iteration step the predicted data are calculated by a forward model for light propagation based on the equation of radiative transfer. The unknown source distribution is updated along a search direction that is provided by an adjoint differentiation technique.