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In this paper we discuss our human computer interaction research on improving the accessibility and supportiveness of information systems for people with cognitive difficulties, whether these are developmental impairments, such as dyslexia, or acquired difficulties, most often an effect of the ageing process. The aetiology and symptoms of these conditions are diverse, yet the challenges they pose to the design of information systems can be addressed using a similar approach (see, for example, Dickinson et al., 2003). The concept of accessibility for this group cannot be an extension of traditional accessibility approaches, which focus on the provision of opportunities to the technically adept: accessibility for this group demands new approaches and a reconsideration of the design of information systems.