A comparison of tiled and overlapping windows
CHI '86 Proceedings of the SIGCHI Conference on Human Factors in Computing Systems
Applying a theory of graphical presentation to the graphic design of user interfaces
UIST '88 Proceedings of the 1st annual ACM SIGGRAPH symposium on User Interface Software
Elastic Windows: evaluation of multi-window operations
Proceedings of the ACM SIGCHI Conference on Human factors in computing systems
Proceedings of the 1999 workshop on new paradigms in information visualization and manipulation in conjunction with the eighth ACM internation conference on Information and knowledge management
Guidelines for using multiple views in information visualization
AVI '00 Proceedings of the working conference on Advanced visual interfaces
Navigation patterns and usability of zoomable user interfaces with and without an overview
ACM Transactions on Computer-Human Interaction (TOCHI)
Image-Browser Taxonomy and Guidelines for Designers
IEEE Software
Cluster and Calendar Based Visualization of Time Series Data
INFOVIS '99 Proceedings of the 1999 IEEE Symposium on Information Visualization
Multiscale Visualization Using Data Cubes "InfoVis 2002 Best Paper"
INFOVIS '02 Proceedings of the IEEE Symposium on Information Visualization (InfoVis'02)
Statistical Inference
VistaClara: an interactive visualization for exploratory analysis of DNA microarrays
Proceedings of the 2004 ACM symposium on Applied computing
BinX: Dynamic Exploration of Time Series Datasets Across Aggregation Levels
INFOVIS '04 Proceedings of the IEEE Symposium on Information Visualization
CGH-Explorer: a program for analysis of array-CGH data
Bioinformatics
Efficient calculation of interval scores for DNA copy number data analysis
RECOMB'05 Proceedings of the 9th Annual international conference on Research in Computational Molecular Biology
Line graph explorer: scalable display of line graphs using Focus+Context
Proceedings of the working conference on Advanced visual interfaces
Process and Pitfalls in Writing Information Visualization Research Papers
Information Visualization
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Recent developments in DNA microarray technology have enabled a new and highly effective platform for performing comparative genomic hybridization (CGH) measurements. CGH measures anomalies in DNA copy number. Such copy number changes are now thought to play an important role in a number of diseases, particularly cancer and developmental disorders, and may also lead to important insights relevant to personalized treatments of such diseases. In contrast to gene expression measurements, the genomic positions of probe targets and their correlation to genomic aberrations lead to a natural ordering of the data. This ordering can be leveraged in data visualizations of CGH measurements. This paper describes a research prototype we have named VistaChrom, which provides a highly interactive, exploratory visualization scheme for analyzing array-based CGH data. For efficient navigation, VistaChrom is based on tiled, multi-level coordinated views organized by genome, chromosome, gene and microarray probe. Raw probe data, moving averages, and statistical measures can all be displayed individually or simultaneously to aid visual discovery of significant genomic aberrations. Visual analysis can be performed with single arrays or multi-array studies. The result is a novel and effective environment for visually analyzing CGH data. Example visualization results are shown for two different data sets derived from tumor cell lines. The application also provides a framework for further exploring advanced computational methods for aberration analysis.