Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
Conceptual Processing during the Conscious Resting State: A Functional MRI Study
Journal of Cognitive Neuroscience
Functional Neuroanatomy of the Semantic System: Divisible by What?
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
Segregating semantic from phonological processes during reading
Journal of Cognitive Neuroscience
Dissociating Reading Processes on the Basis of Neuronal Interactions
Journal of Cognitive Neuroscience
Development of Brain Mechanisms for Processing Orthographic and Phonologic Representations
Journal of Cognitive Neuroscience
The Inferior Frontal Gyrus and Phonological Processing: An Investigation using rTMS
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
Repetition Suppression for Spoken Sentences and the Effect of Task Demands
Journal of Cognitive Neuroscience
Prefrontal Cortical Response to Conflict during Semantic and Phonological Tasks
Journal of Cognitive Neuroscience
The main sources of intersubject variability in neuronal activation for reading aloud
Journal of Cognitive Neuroscience
Modality-and task-specific brain regions involved in chinese lexical processing
Journal of Cognitive Neuroscience
Contrasting effects of vocabulary knowledge on temporal and parietal brain structure across lifespan
Journal of Cognitive Neuroscience
Common and unique neural correlates of autobiographical memory and theory of mind
Journal of Cognitive Neuroscience
The effect of aging on the neural correlates of phonological word retrieval
Journal of Cognitive Neuroscience
Please get to the point! a cortical correlate of linguistic informativeness
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience
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The involvement of the left inferior prefrontal cortex (LIPC) in phonological processing is well established from both lesion-deficit studies with neurological patients and functional neuroimaging studies of normals. Its involvement in semantic processing, on the other hand, is less clear. Although many imaging studies have demonstrated LIPC activation during semantic tasks, this may be due to implicit phonological processing. This article presents two experiments investigating semantic functions in the LIPC. Results from a functional magnetic resonance imaging experiment demonstrated that both semantic and phonological processing activated a common set of areas within this region. In addition, there was a reliable increase in activation for semantic relative to phonological decisions in the anterior LIPC while the opposite comparison (phonological vs. semantic decisions) revealed an area of enhanced activation within the posterior LIPC. A second experiment used transcranial magnetic stimulation (TMS) to temporarily interfere with neural information processing in the anterior portion of the LIPC to determine whether this region was essential for normal semantic performance. Both repetitive and single pulse TMS significantly slowed subjects' reactions for the semantic but not for the perceptual control task. Our results clarify the functional anatomy of the LIPC by demonstrating that anterior and posterior regions contribute to both semantic and phonological processing, albeit to different extents. In addition, the findings go beyond simply establishing a correlation between semantic processing and activation in the LIPC and demonstrate that a transient disruption of processing selectively interfered with semantic processing.