Minimum cost spanning tree situations and gene expression data analysis

  • Authors:
  • Stefano Moretti

  • Affiliations:
  • National Cancer Research Institute (IST), Genoa, Italy

  • Venue:
  • GameNets '06 Proceeding from the 2006 workshop on Game theory for communications and networks
  • Year:
  • 2006

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Abstract

In [16] a methodology based on Game Theory for the analysis of gene expression data is studied. Roughly speaking, the starting point is the observation of a 'picture' of gene expressions in a sample of cells under a biological condition of interest, for example a tumor. Then, Game Theory plays a primary role to quantitatively evaluate the relevance of each gene in regulating or provoking the condition of interest, taking into account the observed relationships in all subgroups of genes. In this paper, an alternative model based on minimum cost spanning tree representation of gene expression data has been introduced. One of the main characteristics of this model is the possibility to avoid the dichotomization technique required for microarray games introduced in [17].