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Digital mammography is one of the most suitable methods for early detection of breast cancer. It uses digital mammograms to find suspicious areas containing benign and malignant microcalcifications. However, it is very difficult to distinguish benign and malignant microcalcifications. This is reflected in the high percentage of unnecessary biopsies that are performed and many deaths caused by late detection or misdiagnosis. A computer based feature selection and classification system can provide a second opinion to the radiologists in assessment of microcalcifications. The research in this paper proposes a neural-genetic algorithm for feature selection to classify microcalcification patterns in digital mammograms. It aims to develop a step-wise algorithm to find the best feature set and a suitable neural architecture for microcalcification classification. The obtained results show that the proposed algorithm is able to find an appropriate feature subset, which also produces a high classification rate.