A computational-intelligence-based approach for detection of exudates in diabetic retinopathy images

  • Authors:
  • Alireza Osareh;Bita Shadgar;Richard Markham

  • Affiliations:
  • Computer Science Department, Engineering Faculty, Shahid Chamran University, Ahvaz, Iran;Computer Science Department, Engineering Faculty, Shahid Chamran University, Ahvaz, Iran;Bristol Eye Hospital, Bristol, U.K.

  • Venue:
  • IEEE Transactions on Information Technology in Biomedicine - Special section on biomedical informatics
  • Year:
  • 2009

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Abstract

Currently, there is an increasing interest for setting up medical systems that can screen a large number of people for sight threatening diseases, such as diabetic retinopathy. This paper presents amethod for automated identification of exudate pathologies in retinopathy images based on computational intelligence techniques. The color retinal images are segmented using fuzzy c-means clustering following some preprocessing steps, i.e., color normalization and contrast enhancement. The entire segmented images establish a dataset of regions. To classify these segmented regions into exudates and nonexudates, a set of initial features such as color, size, edge strength, and texture are extracted. A genetic-based algorithm is used to rank the features and identify the subset that gives the best classification results. The selected feature vectors are then classified using a multilayer neural network classifier. The algorithm was implemented using a large image dataset consisting of 300 manually labeled retinal images, and could identify affected retinal images with 96.0% sensitivity while it recognized 94.6% of the normal images, i.e., the specificity. Moreover, the proposed scheme illustrated an accuracy including 93.5% sensitivity and 92.1% predictivity for identification of retinal exudates at the pixel level.