Possibilistic approach for biclustering microarray data

  • Authors:
  • C. Cano;L. Adarve;J. López;A. Blanco

  • Affiliations:
  • Departamento de Ciencias de la Computación e I.A, E.T.S. Ingeniería Informática, University of Granada, Granada, Spain;Departamento de Ciencias de la Computación e I.A, E.T.S. Ingeniería Informática, University of Granada, Granada, Spain;Departamento de Ciencias de la Computación e I.A, E.T.S. Ingeniería Informática, University of Granada, Granada, Spain;Departamento de Ciencias de la Computación e I.A, E.T.S. Ingeniería Informática, University of Granada, Granada, Spain

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2007

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Abstract

Biclustering has emerged as an important method for analyzing gene expression data from microarray technology. It allows to identify groups of genes which behave similarly under a subset of conditions. As a gene may play more than one biological role in conjunction with distinct groups of genes, non-exclusive biclustering algorithms are required. In this paper we propose a new method to obtain potentially-overlapping biclusters, the Possibilistic Spectral Biclustering algorithm (PSB), based on Fuzzy Technology and Spectral Clustering. We tested our method on S. cerevisiae cell cycle expression data and on a human cancer dataset, validating the obtained biclusters using known classifications of conditions and GO Term Finder for functional annotations of genes. Results are available at http://decsai.ugr.es/~ccano/psb.