A multi-scaled approach to artificial life simulation with P systems and dissipative particle dynamics

  • Authors:
  • James Smaldon;Jonathan Blakes;Natalio Krasnogor;Doron Lancet

  • Affiliations:
  • University of Nottingham, Nottingham, United Kingdom;University of Nottingham, Nottingham, United Kingdom;University of Nottingham, Nottingham, United Kingdom;Weizmann Institute of Science, Rehovot, Israel

  • Venue:
  • Proceedings of the 10th annual conference on Genetic and evolutionary computation
  • Year:
  • 2008
  • Liposome logic

    Proceedings of the 11th Annual conference on Genetic and evolutionary computation

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Abstract

Compartmentalisation is thought to have been a crucial step in the origin of life. To help us bridge the gap between self-assembly processes behind the formation of bio-compartments and metabolic and information bearing processes we refer to DPD and P Systems Simulations. In this paper we outline a new software platform linking a high level abstract computational formalism (P Systems) with a molecular scale model (Dissipative Particle Dynamics) by linking the membranes which delimit the cellular regions within P Systems to self-assembled phospholipid based vesicles in DPD. We test the platform by modelling a passive transport process involving vesicles containing membrane inclusions similar to pore complexes such as ±-hemolysin. In doing so, we illustrate the usefulness of the modelling approach and derive a more realistic parameter set for the P system through the dissipative particle dynamics simulation.