On the Relevance of Cellular Signaling Pathways for Immune-Inspired Algorithms

Authors:
T. S. Guzella;T. A. Mota-Santos
Affiliations:
Dept. of Electrical Engineering, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil 31270-010 and Dept. of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizo ...;Dept. of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil 31270-010
Venue:
ICARIS '08 Proceedings of the 7th international conference on Artificial Immune Systems
Year:
2008

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Abstract

In this conceptual paper, we discuss the relevance of cellularsignaling pathways for immune-inspired algorithms. With complexdynamics, the mapping of environment stimuli to cellular responsesis highlighted as a decision making capability. When consideringapplications which could benefit from these dynamics, thepossibility of incorporating these pathways can be an interestingway to combine more biologically-plausible algorithms and improvedperformance. The structure of the NF-κB (NuclearFactor κB) and MAP (Mitogen-activated protein)kinases pathways, and the pathways involved in signaling byToll-like receptors, are presented. As an example, we then considerhow these pathways could be incorporated in the Dendritic CellAlgorithm.