Formal Language Tools for Template-Guided DNA Recombination

  • Authors:
  • Michael Domaratzki

  • Affiliations:
  • Department of Computer Science, University of Manitoba, Winnipeg, Canada MB R3T 2N2

  • Venue:
  • Language and Automata Theory and Applications
  • Year:
  • 2008

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Abstract

Certain stichotrichous ciliates, single-celled organisms with hair-like structures called cilia, have a well-studied ability to rearrange their DNA during a form of asexual reproduction called conjugation. Ciliates also demonstrate nuclear dualism: each ciliate has both a micronucleus and a macronucleus. The unscrambling of DNA during conjugation occurs when the scrambled version, contained in the micronucleus, is rearranged in a precise way to produce an unscrambled equivalent which forms the macronucleus.