P Systems with Proteins on Membranes
Fundamenta Informaticae
Membrane Systems with Peripheral Proteins: Transport and Evolution
Electronic Notes in Theoretical Computer Science (ENTCS)
Bioinformatics
Towards a complete covering of SBML functionalities
WMC'07 Proceedings of the 8th international conference on Membrane computing
Mitotic oscillators as MP graphs
WMC'06 Proceedings of the 7th international conference on Membrane Computing
Modelling cellular processes using membrane systems with peripheral and integral proteins
CMSB'06 Proceedings of the 2006 international conference on Computational Methods in Systems Biology
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Membrane systems with peripheral proteins are essentially standard membrane systems with the possibility of having multisets of objects (proteins) embedded in the membranes and with the presence of rules that control the transport and the change of configurations of these proteins. The model intends to abstract the activities of the receptors embedded in the cellular membranes. In this paper we use an extension of this paradigm to model and simulate some of the mechanisms underlying cell cycle and breast tumor growth. In particular we have defined a membrane system that abstracts the G2/M cell cycle phase transition and extends the corresponding Reactome model. The model has been then simulated by using the software Cyto-Sim and we have monitored the interplay between activators and inhibitors of the cell cycle.