Membrane Computing: An Introduction
Membrane Computing: An Introduction
On p systems as a modelling tool for biological systems
WMC'05 Proceedings of the 6th international conference on Membrane Computing
P systems and the modeling of biochemical oscillations
WMC'05 Proceedings of the 6th international conference on Membrane Computing
Evolution and oscillation in p systems: applications to biological phenomena
WMC'04 Proceedings of the 5th international conference on Membrane Computing
The metabolic algorithm for P systems: Principles and applications
Theoretical Computer Science
Cell Cycle and Tumor Growth in Membrane Systems with Peripheral Proteins
Electronic Notes in Theoretical Computer Science (ENTCS)
Discrete simulations of biochemical dynamics
DNA13'07 Proceedings of the 13th international conference on DNA computing
WMC'09 Proceedings of the 10th international conference on Membrane Computing
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This paper proposes a model in terms of metabolic P graphs of a few important processes occurring during the biological phase where the choice is made to begin again mitosis or to arrest it. The cellular processes during this phase turn out to be especially interesting in the case of DNA damage, which triggers a specific destruction of Cdc25A phosphatase. It has important implications to understand the role of cell cycle checkpoints and the mechanism(s) guiding the proliferation of UV-resistant tumored cells. The formalism of metabolic P graphs highlights the relevant information of the biological network dynamics, and the individuation of few parameters rules the basic mechanisms of Cdc25A degradation, involving a couple of important mitotic oscillators.