DNA Computing in Microreactors
DNA 7 Revised Papers from the 7th International Workshop on DNA-Based Computers: DNA Computing
Automated Design and Programming of a Microfluidic DNA Computer
Natural Computing: an international journal
Defect-Aware Synthesis of Droplet-Based Microfluidic Biochips
VLSID '07 Proceedings of the 20th International Conference on VLSI Design held jointly with 6th International Conference: Embedded Systems
Towards practical biomolecular computers using microfluidic deoxyribozyme logic gate networks
DNA'05 Proceedings of the 11th international conference on DNA Computing
A microfluidic device for DNA tile self-assembly
DNA'05 Proceedings of the 11th international conference on DNA Computing
Computational biology: a programming perspective
Formal modeling
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There are limits to miniaturization with current computer technologies. Information-processing capabilities of organic molecules such as DNA can be used in computers to replace digital switching modality. However, without the emergence of microfluidic devices, all operations in vitro would be user regulated. A more advanced model is where robotic and electronic regulation is combined with DNA computing allowing the majority of the operations within the test environment to be carried out automatically. Microfluidics offers the promise of a "lab on a chip" system. This can control pico liter scale volumes, with integrated support for operations such as mixing, storage, PCR, heating/cooling, cell lysis, electrophoresis, and others [1], [2]], [3]. Thus has emerged a vision for creating a hybrid DNA computer: that can use microfluidics for the control paths and biological primitives for computation (the Arithmetic Logical Units). This paper presents a proposed modularized DNA biochip computer that works in accordance with Von Neumann's principles [4]. The biochips are divided into several modules, which have different functions. Thus, biochemical operations can be regulated in a step wise fusion. We then describe each module within the biochip and simulate how the classic Hamiltonian Path Problem would be solved in the proposed DNA computer.