A microfluidic device for DNA tile self-assembly

  • Authors:

  • Koutaro Somei;Shohei Kaneda;Teruo Fujii;Satoshi Murata

  • Affiliations:

  • Tokyo Institute of Technology, Yokohama, Japan;The University of Tokyo, Tokyo, Japan;The University of Tokyo, Tokyo, Japan;Tokyo Institute of Technology, Yokohama, Japan

  • Venue:
  • DNA'05 Proceedings of the 11th international conference on DNA Computing
  • Year:
  • 2005

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Abstract

This paper presents a microfluidic device specially designed for DNA tile self-assembly. The DNA tile is one of the most promising building blocks for complex nanostructure, which can be used as a molecular computer or a scaffold for functional molecular machineries. In order to build desired nanostructure, it is necessary to realize errorless self-assembly under thermal fluctuation. We propose a method to directly control environmental parameters of DNA self-assembly such as concentration of each monomer tile and temperature in the reaction chamber by using a microfluidic device. The proposed device is driven by a capillary pump and has an open reaction chamber which enables real-time observation by AFM. Results of preliminary experiments to evaluate performance of the device will be reported.