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Memetic Algorithms have become one of the key methodologies behind solvers that are capable of tackling very large, real-world, optimisation problems. They are being actively investigated in research institutions as well as broadly applied in industry. This article provides a very short introduction to Memetic Algorithms and it is a condensed version of a chapter with the same title that will appear in the Handbook of Natural Computing to be published by Springer [35] in which a pragmatic guide to the key design issues underpinning Memetic Algorithms (MA) engineering is overviewed.