Robust and fast shell registration in PET and MR/CT brain images

  • Authors:
  • Ho Lee;Jeongjin Lee;Namkug Kim;In Kyoon Lyoo;Yeong Gil Shin

  • Affiliations:
  • School of Computer Science and Engineering, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea;Department of Digital Media, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Gyeonggi-do 420-743, Republic of Korea;Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnab 2-dong Songpa-gu, Seoul 138-736, Republic of Korea;Department of Psychiatry, Seoul National University College of Medicine and Hospital, 101 Daehang-ro, Jongro-gu, Seoul 110-744, Republic of Korea;School of Computer Science and Engineering, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2009

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Abstract

A robust and fast hybrid method using a shell volume that consists of high contrast voxels with their neighbors is proposed for registering PET and MR/CT brain images. Whereas conventional hybrid methods find the best matched pairs from several manually selected or automatically extracted local regions, our method automatically selects a shell volume in the PET image, and finds the best matched corresponding volume using normalized mutual information (NMI) in overlapping volumes while transforming the shell volume into an MR or CT image. A shell volume not only can reduce irrelevant corresponding voxels between two images during optimization of transformation parameters, but also brings a more robust registration with less computational cost. Experimental results on clinical data sets showed that our method successfully aligned all PET and MR/CT image pairs without losing any diagnostic information, while the conventional registration methods failed in some cases.