A progressive-ILP-based routing algorithm for the synthesis of cross-referencing biochips

Authors:
Ping-Hung Yuh;Sachin S. Sapatnekar;Chia-Lin Yang;Yao-Wen Chang
Affiliations:
Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan;Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN;Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan;Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan and Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan
Venue:
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Year:
2009

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Abstract

Due to recent advances in microfluidics technology, digital microfluidic biochips and their associated computer-aided-design problems have gained much attention, most of which has been devoted to direct-addressing biochips. In this paper, we solve the droplet routing problem under the more scalable cross-referencing biochip paradigm. We propose the first droplet routing algorithm that directly solves the problem of routing. We first present an optimal basic integer-linear-programming (ILP) formulation. Due to its complexity, we also propose a progressive-ILP scheme to determine the locations of droplets at each time step. Simulation results demonstrate the efficiency and effectiveness of our algorithm.